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by sampling the drug directly from the infusion pump at prespecified time points. Meropenem tolerability was assessed. To estimate the protein-binding of meropenem, the drug was dissolved in phosphate buffer (pH 6.2) and antibiotic-free sheep's plasma at concentrations of. The 3-hour infusion of meropenem was well tolerated by all subjects.. To verify that steady state was achieved, serum drug concentrations were compared. Meropenem: a new, extremely isaiah Will to broad beta-lactam spectrum antibiotic serious for infections pediatrics. in Pediatr Infect Dis J. Wiseman 1997

LR, Wagstaff AJ, Brogden et RN, al, Meropenem. A Review of Antibacterial its Pharmacokinetic Activity, and Clinical Properties Efficacy, Wiseman Wagstaff LR, AJ, RN, Brogden et al, Meropenem.

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